Keep track of Intently (3)pentobarbital will lessen the extent or influence of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Potent or reasonable CYP3A4 inducers could raise level of diazepam elimination; hence, efficacy of diazepam could be diminished.pentobarbital will minimize the extent or ou